"Oh, you didn't actually think I could give perks that affect powers everywhere in the multiverse, did you?"
The perks: Blank, Trumped the Trump, All Seeing Precognition, and Plot Amour no longer work everywhere. Instead, they are limited to the multiverse cluster you start in.
If you choose the setting "Canon Earth Bet" or "AU Earth Bet" the range is limited to what the entities can reach (1080 universes). For "Crossover" and "AU Crossover" it includes the multiverses of any settings you select. For "Alternate Earth" includes the multiverse of your chosen destination(s). And "No Transfer" places you in the Worm multiverse.