You have 7 slots (10 with negentropy) which can either be filled with a skill or a Thinker power.
When you slot in a skill, you can use it at the highest possible level. These skills include the mastery of a single style of martial arts, a field of medicine or science, cooking, juggling, and more. Anything that can be learned you can have. Skills that require a muscle memory provide it.
The Thinker powers you can have are limited to at most a rating of 5 on the PRT scale. Powers that operate on your senses and observations will tend to be more accurate than those that require external information (like precognition).